CAS No.53-84-9
中文名稱(chēng)(Chinese name):煙酰胺腺嘌呤二核苷酸
中文別名(Chinese aliases):β-煙酰胺腺嘌呤雙核苷酸
英文名稱(chēng)(English name):β-Nicotinamide adenine dinucleotide
英文別名(English aliases):NAD
CAS No.53-84-9
分子式(Molecular formula):C21H27N7O14 P2
分子量(Molecular weight):663.43
分子結(jié)構(gòu)(structural formula):
物化性質(zhì)(Physical properties):
本品為白色或類(lèi)白色粉末。
This product is a white to off-white powder.
純度(Purity)HPLC:≥98.0%
貯藏(storage):密封,冷凍保存。Preserve in tight containers, in a freezing place.
應(yīng)用領(lǐng)域(Application field)
1. 能量代謝
NAD? 在細(xì)胞的能量代謝中扮演著至關(guān)重要的角色,特別是在糖酵解、三羧酸循環(huán)(TCA循環(huán))和氧化磷酸化過(guò)程中。
2. DNA修復(fù)與衰老
NAD? 是聚腺苷二磷酸核糖聚合酶 (PARP) 的底物,這是一種參與DNA修復(fù)的酶。
3. Sirtuins與基因表達(dá)調(diào)控
NAD? 是 Sirtuins 家族酶(依賴(lài)NAD?的去乙酰化酶)的必需輔酶,Sirtuins 參與調(diào)控基因表達(dá)、代謝過(guò)程、抗氧化反應(yīng)和衰老。
4. 免疫系統(tǒng)和炎癥反應(yīng)
NAD? 還參與調(diào)節(jié)免疫系統(tǒng)的功能和炎癥反應(yīng)。
5. 神經(jīng)系統(tǒng)功能
NAD? 在神經(jīng)元功能和腦健康中也起到重要作用。
參考文獻(xiàn):
[1] Lehninger, A. L., Nelson, D. L., & Cox, M. M. (2008). Lehninger Principles of Biochemistry (5th ed.). W.H. Freeman.
[2] Houtkooper, R. H., & Auwerx, J. (2012). Exploring the therapeutic space around NAD?. Journal of Cell Biology, 199(2), 205-207.
[3] Belenky, P., Bogan, K. L., & Brenner, C. (2007). NAD? metabolism in health and disease. Trends in Biochemical Sciences, 32(1), 12-19.
[4] Imai, S., & Guarente, L. (2014). NAD? and sirtuins in aging and disease. Trends in Cell Biology, 24(8), 464-471.
[5] Haigis, M. C., & Sinclair, D. A. (2010). Mammalian sirtuins: biological insights and disease relevance. Annual Review of Pathology: Mechanisms of Disease, 5(1), 253-295.
[6] Verdin, E. (2015). NAD? in aging, metabolism, and neurodegeneration. Science, 350(6265), 1208-1213.
[7] Chini, E. N., et al. (2020). The NADase CD38 is a key regulator of NAD? homeostasis in metabolic aging. Nature Metabolism, 2(7), 291-300.
[8] Mills, K. F., et al. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metabolism, 24(6), 795-806.
[9] Fang, E. F., et al. (2016). NAD? rejuvenates aged gut adult stem cells. Aging Cell, 15(4), 524-536.
[10] Verdin, E., et al. (2020). NAD? boosting in neurodegenerative disorders: The sirtuin pathway. Cell Research, 30(8), 609-610.